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KMID : 1094020180350050211
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Journal of Veterinary Clinics
2018 Volume.35 No. 5 p.211 ~ p.214
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Combination Therapy of Prednisolone and Toceranib Phosphate in a Dog with Malignant Metastatic Insulinoma
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Kang Yeo-Lim
Park Hee-Myung
Kang Min-Hee
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Abstract
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A 14-year-old intact female Yorkshire terrier was presented with a 2-month history of shivering, intermittentpelvic limb weakness and collapse. Biochemical abnormalities revealed inappropriately increased serum insulinconcentration with persistent hypoglycemia. Abdominal ultrasound revealed multiple various sized nodules in liver andfine-needle aspirates of the nodule showed typical neuroendocrine cells with high cellularity. Computed tomography(CT) revealed well-defined hyperattenuating mass in the right pancreatic lobe with homogenous enhancement. CTfindings were consistent with a pancreatic tumor with malignant metastasis. Treatment was initiated with low-doseprednisolone and toceranib phosphate. The dog was maintained stable with no more progression of clinical signs andit is worth to try toceranib phosphate in a dog with metastatic insulinoma for improving the quality of life.
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KEYWORD
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Canine, hypoglycemia, malignant insulinoma, toceranib phosphate
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